Blinken's meeting with Xi on the final day of his two-day visit will be the first time a US secretary of state has met the Chinese leader since 2018, and it could help to facilitate a summit between Xi and US President Joe Biden later in the year.
"Secretary Blinken will meet with People's Republic of China President Xi Jinping at 4.30pm (local time)," a State Department official said.
Making the first visit to China by a US secretary of state in five years, Blinken held extensive discussions with China's top diplomat Wang Yi on Monday, and foreign minister Qin Gang on Sunday.
The talks, held at the Diaoyutai state guest house in Beijing, did not appear to make much progress in bridging the two sides' differences on issues ranging from Taiwan to trade, human rights, stemming the flow of synthetic opioid fentanyl or their approach to the war in Ukraine.
Describing the US-China relationship as being at a low point, Wang said the root cause was the United States' wrong perception of China.
Blinken underscored the importance of open communication channels to manage their competition during more than three hours of talks with Wang, the State Department said, calling their conversation as "productive."
"We must take a responsible attitude toward the people, history and the world, and reverse the downward spiral of US-China relations," Wang said during the meeting with Blinken, according to a statement released by China's foreign ministry.
Wang urged the United States to stop speculating on threats from China, abandon its "suppression" of China's scientific and technological development, and refrain from interfering in its internal affairs, according to Chinese state media.
The lack of regular and open communication channels between the world's top two economies has sent jitters around the world. Beijing's reluctance to engage in regular military-to-military talks with Washington has alarmed China's neighbours.
During seven-and-a-half hours of talks with Qin on Sunday, Blinken stressed "the need to reduce the risk of misperception and miscalculation", the State Department said.
Both sides emphasised the importance of making it easier for their citizens to visit, and agreed on working to increase passenger flights, which boosted Chinese airline shares.
They also expressed a desire to stabilise bilateral ties despite what one US official called their "profound" differences, and agreed that Qin would visit Washington to continue the conversation, though no date was announced.
"This is going to be a process of sustained diplomacy," one senior State Department official, speaking on the condition of anonymity, said on Sunday.
Blinken's trip, which was postponed in February after a suspected Chinese spy balloon flew over US airspace, is closely followed worldwide as further deterioration of ties between the world's two largest economies could have global implications on financial markets, trade practices and routes and supply chains.
Beijing's tone on Taiwan, the democratic island Beijing claims as it own, has been particularly pointed throughout Blinken's visit.
Wang said "China has no room for compromise or concessions", according to the Chinese readout.
The United States has long stuck to a policy of "strategic ambiguity" over whether it would respond militarily to an attack on Taiwan, which Beijing has refused to rule out.
When asked last year, US President Joe Biden said Washington would defend Taiwan in the event of a Chinese invasion, though aides later said his comments did not reflect a policy departure from the long-standing "one China" policy.
