Renegades captain Will Sutherland and fellow pacer Fergus O'Neill were both banned from bowling for the rest of the Heat's innings following intervention from umpire Donovan Koch.
Sutherland was taken out of the attack with a ball to go in his third over after Donovan spoke to him, while O'Neill still had nine deliveries he could have bowled for the innings.
It is rare for one player to be removed from bowling mid-over, but two in the same match is virtually unheard of.
Renegades opener Josh Brown, who has never bowled before in his 37 previous T20 appearances, was forced to fill the void left by Sutherland and O'Neill.
Brown's 2.4 overs went for a whopping 0-48, as the Heat piled on 4-196 - the highest total at Marvel Stadium this season - from their 20 overs
Sutherland had a nightmare start to the match, twice being hit for three-consecutive sixes - first by Jack Wood in the third over, then by Matt Renshaw in the 12th.
If the Heat win, they will move into fourth on the table and will be guaranteed of playing in the BBL finals if the Melbourne Stars lose against the Hobart Hurricanes on Sunday night.