Peter O'Mahony will lead the team from blindside flanker for the first of the two test series against last year's World Cup winners.
The 22-year-old Osborne usually plays centre for Leinster, but was brought in to replace Hugo Keenan who has joined Ireland's sevens team for the Paris Olympics.
Craig Casey was chosen to replace injured Jamison Gibson-Park, condemning British & Irish Lions veteran Conor Murray to a further stint on the replacements' bench.
Coach Andy Farrell went for an orthodox five-three forward-backs split on the bench.
Ireland: Jamie Osborne, Calvin Nash, Robbie Henshaw, Bundee Aki, James Lowe, Jack Crowley, Craig Casey, Caelan Doris, Josh van der Flier, Peter O'Mahony (c), Tadhg Beirne, Joe McCarthy, Tadhg Furlong, Dan Sheehan, Andrew Porter
Replacements: Ronan Kelleher, Cian Healy, Finlay Bealham, James Ryan, Ryan Baird, Conor Murray, Ciaran Frawley, Garry Ringrose.
