Opener Reeza Hendricks smashed 117 runs from 63 balls to guide South Africa to a seven-wicket victory over Pakistan in the second Twenty20 International at Centurion Park.
The win claimed the three-match series 2-0 with a game to spare and marked the first time in more than two years the Proteas have won a bilateral Twenty20 series.
Pakistan elected to bat first and, boosted by an unbeaten 98 from 57 balls by opener Saim Ayub, posted 5-206 in their 20 overs.
But on a good batting wicket, South Africa overcame a sluggish start to reach their target with three balls to spare as the brilliant Hendricks scored a maiden T20 International century that included 10 sixes.
He put on 157 in a partnership with Rassie van der Dussen, who was unbeaten on 66 from 38 balls as the latter guided the hosts over the line.
It is a record for the third wicket for South Africa, while Hendricks reached 50 for the 18th time in T20 Internationals, the most for South Africa and one more than Quinton de Kock.
The third and final match of the series will be played in Johannesburg on Saturday, before the teams play three ODIs and two Tests in an all-format tour.
Former fast bowler Aaqib Javed will coach Pakistan following the  resignation of ex-Australia quick Jason Gillespie as Test team mentor.
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